RAF Typhoon FGR4s have conducted a mission with French warplanes in a joint strike on an hidden munitions depot in Syrian territory employed by the IS group, per a report from the British defence ministry.
The location, identified by surveillance, was thought to be housing weapons and explosive materials, the statement said, and was located in mountainous terrain just above Palmyra in Syria's central region.
"The RAF jets used laser-guided Paveway IV weapons to strike a several approach shafts down to the site... initial indications suggest the strike was effective," the ministry announced.
There was no evidence of any harm to civilians in the strike conducted Saturday night and all the aircraft returned safely, the ministry further stated.
The British jets were assisted by a Voyager aerial refuelling aircraft.
The Islamic State group - also known as ISIS - established extremist governance over large swathes of Iraq and Syria before its territorial defeat in 2019.
"This operation demonstrates the UK's leading role, and commitment to operate in unison with allied nations, to eradicate any revival of IS and their harmful and extremist ideologies in the region," Britain's Defence Chief John Healey said.
British military aircraft have performed surveillance missions over Syria to "prevent any attempted resurgence" of IS after its military defeat at the Baghuz confrontation in 2019, the ministry said.
"I extend gratitude to every member of the UK armed forces participating in this mission for their skill and their bravery," Healey added. "Including them were numerous British personnel deployed over Christmas and New Year. This operation, to eliminate militants who threaten our safety, demonstrates how UK forces are ready to step up, throughout the year, keeping Britain secure within its borders and strong abroad."
In December, the US military carried out what it described as a "massive strike" targeting Daesh sites in the country, after an attack killed two US servicemembers and a local interpreter in the Palmyra area.
The UN says Islamic State still has an estimated 5,000 to 7,000 militants in Syria and Iraq.